An atlas of the aging lung mapped by single cell ... - Nature
WEBFeb 27, 2019 · Here, we use single cell transcriptomics and mass spectrometry-based proteomics to quantify changes in cellular activity states across 30 cell types and chart the lung proteome of young and old...
A single-cell atlas of mouse lung development - PubMed
WEBDec 15, 2021 · We provide an integrated view of cellular dynamics in epithelial, endothelial and mesenchymal cell populations during lung organogenesis. Keywords: Lung development; Mouse; Progenitor cells; RNA velocity; Single-cell transcriptomics; Type 1 …
Age-Related Structural and Functional Changes in the Mouse Lung
WEBDec 4, 2019 · Lung function declines with advancing age. To improve our understanding of the structure-function relationships leading to this decline, we investigated structural alterations in the lung and their impact on micromechanics and …
The normal and fibrotic mouse lung classified by spatial …
WEBMay 24, 2022 · Classification and frequency of cell types in controls and treated mice. The cell types identified in the lungs are shown as mean ± SD for individual mice for each treatment.
Measuring the lung function in the mouse: the challenge of size
WEBMay 15, 2003 · Since these studies, the use of mice to study lung disease has increased dramatically and a number of approaches have been developed in the ensuing years for measuring lung function in mice in vivo. In this review we examine these various methods and discuss their respective attributes.
Optimizing anesthesia and delivery approaches for dosing into lungs of mice
WEBIn this study, we found that anesthetic approach and administration route can affect the efficiency of fluid dosing to lungs of mice with impacts on experimental power in models of viral and bacterial pneumonia.
A single-cell atlas of mouse lung development | Development
WEBDec 20, 2021 · We provide an integrated view of cellular dynamics in epithelial, endothelial and mesenchymal cell populations during lung organogenesis. Keywords: Lung development, Single-cell transcriptomics, Progenitor cells, RNA velocity, Type 1 pneumocyte, Mouse.
A single-cell atlas of mouse lung development - PMC
WEBDec 12, 2021 · To assess the cellular landscape of the developing mouse lung (between E12 and P14), single-cell suspensions were generated from dissociated whole lung tissue (at least four mice per time point were pooled), parenchymal [CD45−/Ter119−] cells were sorted by fluorescence-activated cell sorting (FACS) …
Mouse lung mechanical properties under varying inflation
WEBMay 2, 2022 · Mice are widely used in the study of lung pathologies, but there is a lack of fundamental mechanical measurements assessing the interdependent effect of varying inflation volumes and cycling...
Comprehensive anatomic ontologies for lung development: A …
WEBOct 24, 2019 · In the mouse, the alveolar stage of lung development begins postnatally around P4 and is complete by P36 [32, 36]. In contrast, this stage of human lung development begins prior to birth, at approximately 36 weeks of gestational age (GA), and continues after birth into the first few years of life [41].
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