Great Falls is a town in Chester County, South Carolina, United States and is located fourteen miles southwest of Lancaster, South Carolina. The population was 1,951 at the 2020 census. The Great Falls Depot, Great Falls Downtown Historic District, and Republic Theater are listed on the National Register of Historic Places. The town council of Great Falls …Great Falls is a town in Chester County, South Carolina, United States and is located fourteen miles southwest of Lancaster, South Carolina. The population was 1,951 at the 2020 census. The Great Falls Depot, Great Falls Downtown Historic District, and Republic Theater are listed on the National Register of Historic Places. The town council of Great Falls was the defendant-respondent found to have violated the Establishment Clause through their invocation of Christian prayer before meetings.