The barrage appeared to be one of the largest recent assaults in Ukraine’s campaign to damage Russia’s war machine on its home territory.

Ukraine struck Russian regions with a major drone and missile attack overnight, damaging at least two factories and forcing schools to close in a major southern Russian city, according to Russian officials and media.

Flight restrictions were imposed at five airports in Russia after Ukraine unleashed an attack reportedly with more than 200 drones and ballistic missiles. Alexander Bogomaz, the governor of the Bryansk region in western Russia, said Ukraine had launched a major missile attack but did not say which missiles had been used.

Ukraine claimed Saturday to have struck one of Russia’s largest oil refineries in a drone attack, starting a fire at the facility more than 700 miles into Russian territory.

Ukrainian forces used missiles and drones on Tuesday to target sensitive military and energy sites across Russia.