Grey's Anatomy' has been renewed for a historic season 21. Here's what we know so far about 'Grey's Anatomy' season 21, including cast, release date and more.

Grey’s Anatomy season 21 will premiere on Sept. 26, and an exclusive trailer teased lots of drama in store for Ellen Pompeo’s Meredith, as well as seeing two beloved characters making their return.

Grey's Anatomy fans are not going anywhere. Earning our loyalty took a lot of work, but we're in it for the long haul.

Jesse Williams makes a return to the hit medical drama "Grey's Anatomy," and he's joined by another familiar face. Ellen Pompeo, who plays Dr. Meredith Grey will also guest star for seven episodes during the 21st season.

Grey's Anatomy fans need season 21, stat - especially after that spring cliffhanger where multiple doctors were fired. "I'm really excited for fans to see how we get out of the end of last season," Grey's showrunner Meg Marinis told Entertainment Weekly in September 2024.

Jo Wilson (Camilla Luddington) is also facing her own challenges, grappling with her pregnancy while keeping the news from Link (Chris Carmack)

If you’ve spent all summer counting down the days until Grey’s Anatomy is back on your TV, you’re in luck because new episodes are finally right around the corner. Thursday, September 26, marks the beloved show’s season 21 premiere on ABC,

As anticipation builds for the premiere of 'Grey's Anatomy' season 21 on September 26, fans were treated to an electrifying trailer that teases not only the intense storylines but also the return of two beloved characters.

Grey’s Anatomy is back with new patients and drama among the characters in season 21 of the medical show. With the trailer released by the ABC Network on Thursday, September 19, the fans got a sneak peek into what could be expected of the episodes that are set to be released by the end of the month.