BMJ1d
Effect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial
Dr C H M van den Ende, Leiden University Medical Centre, Department of Rheumatology, C4-R, Postbox 9600, 2300 RC Leiden, The Netherlands Email:e.vandenende{at}nivel.nl OBJECTIVE To investigate the ...
BMJ1d
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial
Objective Randomised trials of type I anti-CD20 antibodies rituximab and ocrelizumab failed to show benefit in proliferative lupus nephritis (LN). We compared obinutuzumab, a humanised type II ...
BMJ1d
AB0412 Preclinical PK and Safety Assessment of the Proposed Adalimumab Biosimilar Gp2017, Compared to Humira®
Background TNFα inhibitors are highly effective drugs for the treatment of inflammatory disorders such as rheumatoid arthritis. Biosimilars are approved biologics with comparable quality, safety and ...
BMJ1d
EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis
Correspondence to Dr Annette H M van der Helm-van Mil, Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden 2300 RC, The Netherlands; AvdHelm{at}lumc.nl Background ...
BMJ2d
Influence of active versus placebo control on treatment responses in randomised controlled trials in rheumatoid arthritis
Correspondence to Professor Daniel Aletaha, Department of Medicine III, Medical University of Vienna, Wien 1090, Austria; daniel.aletaha{at}meduniwien.ac.at Objectives To investigate whether treatment ...
BMJ2d
Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology
2 Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK 3 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK 4 Institute of ...
BMJ3d
The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study
Correspondence to A Willemien Visser, Department of Rheumatology, Leiden University Medical Center, C1-R, P.O. Box 9600, Leiden 2300 RC, The Netherlands; a.w.visser{at}lumc.nl Objective To study the ...
BMJ4d
Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis, but do not predict a flare of synovitis
1 Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy 2 Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genova, Italy 3 Università degli ...
BMJ4d
Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
11 Paris-Descartes University, Medicine Faculty, UPRES-EA 4058 & APHP, Cochin Hospital, Rheumatology B Department, Paris, France Correspondence to Professor Maxime Dougados, Paris-Descartes University ...
BMJ4d
Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
Objective We aimed to understand the role of the transcriptional co-factor Yes-associated protein (Yap) in the molecular pathway underpinning the pathogenic transformation of synovial fibroblasts (SF) ...
BMJ4d
DNA methylome signature in rheumatoid arthritis
1 Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, USA 2 Department of Chemistry and Biochemistry, University of California San Diego School of ...
BMJ6d
Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis
Objective Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) characterised by a vicious cycle of immune amplification that can ...