An essential part of suicide prevention, especially amid ongoing drug overdoses, is recognizing the link between suicide and ...

setting in motion a sci-fi/horror parable in which her dependence on this substance ends up hastening her downfall instead of holding it off. It’s hard to pinpoint a “downfall” moment in Moore’s ...

The first big update to U.S. methadone regulations in 20 years is poised to expand access to the life-saving drug starting ...

Addiction involves loss of control over use of a substance, often in the presence of physiological and psychological dependence on a substance and compulsion to continue seeking and using the ...

“There exist but the thousands of mirrors that reflect me.” Something of “The Eye” lurks in “The Substance,” Coralie Fargeat’s mirror-haunted gory fable about fame, self-hatred and ...

The Substance overflows with brilliant, disgusting, and hilarious body horror. The Substance is an awesome accomplishment of design, from the clinical-yet-do-it-yourself instructions of the ...

The FBI and U.S. Postal Inspection Service are investigating a series of suspicious letters, some of which contained an unknown substance, sent to election officials nationwide, the agencies ...

This is, of course, the titular Substance being injected: an elixir that promises a younger, more beautiful alter ego, but only if you are willing to pay the price and inflict unspeakable violence ...

“The Substance” is smart, gross, funny, brave, maddening, insightful, hard to watch, impossible to turn away from —what else do you want in a movie? Coralie Fargeat’s film — she wrote ...

Pre-Covid, they would most likely debut in a few New York and Los Angeles theaters. “The Substance” isn’t a hard sell for a wider release. There’s strong advance interest among cinephiles ...

This image released by Mubi shows Demi Moore in a scene from "The Substance." (Mubi via AP) In its first two hours, “The Substance” is a well-made, entertaining movie. Writer-director Coralie ...