Imlunestrant with or without Abemaciclib in Advanced Breast Cancer
Dec 11, 2024 · Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the …
Hydrocortisone in Severe Community-Acquired Pneumonia - The …
Mar 21, 2023 · Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is …
The Emerging Threat of H5N1 to Human Health - The New …
Dec 31, 2024 · Against this background, more humans have come into contact with HPAI A (H5N1). Investigators now report in the Journal a series of human cases from the United …
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without ...
Jun 14, 2024 · Tenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the …
Management of Insomnia - The New England Journal of Medicine
Jul 17, 2024 · Insomnia is common and frequently occurs with other disorders. First-line cognitive behavioral therapy with or without medication can produce rapid, sustained alleviation of …
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe …
Oct 28, 2024 · For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 …
Pulmonary Arterial Hypertension - The New England Journal of …
Dec 15, 2021 · Without effective treatment, pulmonary arterial hypertension results in high morbidity and mortality. This review discusses the pathogenesis of the disorder, the thorough …
Defibrillation Strategies for Refractory Ventricular Fibrillation | New ...
Nov 6, 2022 · Despite advances in defibrillation technology, shock-refractory ventricular fibrillation remains common during out-of-hospital cardiac arrest. Double sequential external defibrillation …
Perioperative Durvalumab with Neoadjuvant Chemotherapy in …
Sep 15, 2024 · The results of this trial support the use of perioperative durvalumab with neoadjuvant chemotherapy as a potential new treatment option for cisplatin-eligible patients …
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
Feb 28, 2018 · Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with …