Imlunestrant with or without Abemaciclib in Advanced Breast Cancer
Dec 11, 2024 · Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα ...
Hydrocortisone in Severe Community-Acquired Pneumonia - The …
Mar 21, 2023 · Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear. In this phase 3, multicenter,...
The Emerging Threat of H5N1 to Human Health - The New …
Dec 31, 2024 · Against this background, more humans have come into contact with HPAI A (H5N1). Investigators now report in the Journal a series of human cases from the United States and Canada. 2,3 The former ...
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without ...
Jun 14, 2024 · Tenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the effectiveness of tenectepla...
Management of Insomnia - The New England Journal of Medicine
Jul 17, 2024 · Insomnia is common and frequently occurs with other disorders. First-line cognitive behavioral therapy with or without medication can produce rapid, sustained alleviation of insomnia symptoms.
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe …
Oct 28, 2024 · For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from ra...
Pulmonary Arterial Hypertension - The New England Journal of …
Dec 15, 2021 · Without effective treatment, pulmonary arterial hypertension results in high morbidity and mortality. This review discusses the pathogenesis of the disorder, the thorough clinical evaluation requir...
Defibrillation Strategies for Refractory Ventricular Fibrillation | New ...
Nov 6, 2022 · Despite advances in defibrillation technology, shock-refractory ventricular fibrillation remains common during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED; rapid...
Perioperative Durvalumab with Neoadjuvant Chemotherapy in …
Sep 15, 2024 · The results of this trial support the use of perioperative durvalumab with neoadjuvant chemotherapy as a potential new treatment option for cisplatin-eligible patients with muscle-invasive bladder ...
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
Feb 28, 2018 · Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with hydrocortisone plus flud...